Escherichia coli in community urinary tract infections: commensal or pathogenic?

Nov. 19, 2021

To study Escherichia coli pathogenicity in urinary tract infections and their relationship with the host. Association of bacteriuria by E. coli with defined pathogenicity criteria or host specific conditions, in women aged up to 59 years.

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Ureteropelvic junction obstruction caused by Fibroepithelial polyps in children

Nov. 19, 2021

Fibroepithelial polyps are extremely rare benign tumors arising from mesodermal tissue in the ureteral wall in children, that can cause ureteropelvic junction obstruction.

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Focal therapies for the treatment of localized prostate cancer: The role of irreversible electroporation – Present or future?

Nov. 19, 2021

In the PSA era, the incidence of localized prostate cancer has been increasing. This reality requires new therapeutic strategies, in order to give an answer to patients, in whom active surveillance may be indicate but desire more interventionist strategy with minimal side effects and without compromising cancer control. In these cases, focal therapies that include irreversible electroporation may be effective alternative strategies.

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Oncocitoma renal: tem a URO‐TC utilidade no diagnóstico histológico?Renal oncocytoma: Is URO‐CT useful in histological diagnosis?

Nov. 19, 2021

Ao longo dos últimos anos, a crescente utilização de exames imagiológicos, nomeadamente ecografia e tomografia computorizada (TC), traduziu‐se num aumento do diagnóstico incidental de tumores renais, sobretudo pequenas massas renais (< 4 cm). O conhecimento de que até 30% destas massas podem ser benignas, entre elas os oncocitomas, levou à procura de métodos de diagnóstico mais eficazes, de forma a evitar situações de sobretratamento e de forma a tomaram‐se decisões terapêuticas mais fundamentadas.

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PET/CT com Fluorocolina‐F18 no estadiamento inicial do carcinoma da próstata18F‐Fluorocholine PET/CT in prostate cancer initial staging

Nov. 19, 2021

Na avaliação do carcinoma da próstata são habitualmente utilizados nomogramas clínicos para prever a probabilidade de disseminação linfática e extra ganglionar. Esses nomogramas podem sugerir a presença e a extensão desta neoplasia, mas não permitem a distinção clara entre doença loco regional e à distância. Pretendeu‐se, com este trabalho, avaliar a utilidade da tomografia por emissão de positrões/tomografia computorizada (PET/CT) com Fluorocolina‐F18 (FCH‐F18) na orientação de doentes com o diagnóstico inicial de carcinoma da próstata e estadiados por esta técnica imagiológica.

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The utility of apparent diffusion coefficient values in the risk stratification of prostate cancer using a 1.5 T magnetic resonance imaging without endorectal coil

Nov. 19, 2021

To evaluate the relationship between mean apparent diffusion coefficient (ADC) and post-surgical Gleason scores. To determine the diagnostic accuracy of multiparametric magnetic resonance imaging (mp-MRI) on a 1.5 T magnet in distinguishing low, intermediate and high-grade prostate tumors.

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Próteses penianas no tratamento da disfunção erétil: a casuística de 13 anosPenile prosthesis in treatment of erectile dysfunction: 13‐year experience

Nov. 19, 2021

A colocação de próteses penianas (PP) é um tratamento comum e bem estabelecido na correção da disfunção erétil (DE) refratária ou com contraindicação ao tratamento médico.

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Validation and invalidation of SARS-CoV-2 main protease inhibitors using the Flip-GFP and Protease-Glo luciferase assays

Nov. 19, 2021

SARS-CoV-2 main protease (Mpro) is one of the most extensively exploited drug targets for COVID-19. Structurally disparate compounds have been reported as Mpro inhibitors, raising the question of their target specificity. 

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Characterization of a novel bispecific antibody targeting tissue factor-positive tumors with T cell engagement

Nov. 19, 2021

T cell engaged bispecific antibody (TCB) is an effective immunotherapy for cancer treatment. Through co-targeting CD3 and tumor-associated antigen (TAA), TCB can redirect CD3+ T cells to eliminate tumor cells regardless of the specificity of T cell receptor.

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The regulatory and modulatory roles of TRP family channels in malignant tumors and relevant therapeutic strategies

Nov. 19, 2021

Transient receptor potential (TRP) channels are one primary type of calcium (Ca2+) permeable channels, and those relevant transmembrane and intracellular TRP channels were previously thought to be mainly associated with the regulation of cardiovascular and neuronal systems. 

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