Histopathology of Mycosis Fungoides in a Colombian Population: Towards the Characterization of South American Populations

Nov. 19, 2021

Recognition of the typical histopathological findings of mycosis fungoides (MF) can help clinicians
establish diagnosis and is of prognostic value for disease progression and treatment response.
Although the histopathological characteristics of MF have been recorded since the earliest
descriptions, peculiarities within the Colombian population have not been explored to date. Our
objective was to describe the histopathology of MF in biopsy samples obtained at the
Dermatopathology Laboratory of the University of Antioquia, Medellín, Colombia.
We reviewed all biopsy data collected at the Dermatopathology Laboratory of the University of
Antioquia between March 1976 and January 2013. These results corresponded to clinical data and
hematoxylin–eosin staining from 252 preselected confirmed diagnoses of cutaneous T-cell
lymphoma, MF, parapsoriasis, and follicular mucinosis. Other lymphomas, Sézary syndrome, and
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post-treatment biopsies were excluded from our analysis. Of the selected samples, 90 corresponded
to a diagnosis of MF. Data on HTLV 1 status were not available for any of the cases analyzed.
The median age (available in 87 of 90 cases) was 52 years, which is lower than that reported in the
United States and Japan (58 and 55 y, respectively).1,2 Time to diagnosis was 3.8 years (range, 1 mo
to 20 y), which is similar to that reported in recent studies. Strikingly, in 4 cases the reported
clinical lesions were papules, and folliculotropism was described in only 1 case. Papules could be
considered an initial lesion in the progression towards plaque formation. However, a clinical variant
of papular MF has been described.3
The histopathological findings according t

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