SARS-CoV-2 Spike-like Pigmented Peripheral Structures: A Dermoscopic Finding in Dysplastic Nevi and Incipient Melanomas

Nov. 19, 2021

The journal Nature1 recently published an article featuring an image (Fig. 1) that immediately caught our attention. If the image was shown in a Rorschach test, a virologist would probably say “coronavirus”, but a dermatologist trained in dermoscopy might well say “a growing melanocytic nevus” or even “melanoma”.

Figure 1. Colored transmission electron micrograph showing a SARS-CoV-2 particle isolated from a patient with COVID-19 in the United Kingdom. ©National Infection Service, United Kingdom/Science Photo Library/agefotostock.

Note the characteristic outward projecting spikes or protuberances on the surface and the markedly irregular rim and somewhat heterogeneous morphology.

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